The Conn Job

Episode 2: Brain Donation-The Most Powerful Gift You'll Never See

Ann Conn Season 1 Episode 2

A Conversation with Dr. Sabina Berretta


In this extraordinary episode of The Conn Job, Dr. Ann Conn sits down with Dr. Sabina Berretta, MD, PhD—Director of the Harvard Brain Tissue Resource Center (HBTRC) at McLean Hospital, part of the NIH Neurobiobank.


Dr. Berretta is a globally recognized leader in human brain research whose work has transformed our understanding of psychiatric and neurological illness.
This conversation explores one of the most profound contributions any person can make to science: brain donation. It is the cornerstone of progress in Alzheimer’s, schizophrenia, bipolar disorder, depression, addiction, PTSD, Parkinson’s disease, and more—yet it remains widely misunderstood.


This episode is deeply personal for Dr. Conn, who has pledged to donate her own brain to the HBTRC in honor of her sons, Austin and Colin, whose deaths during psychotic episodes propel her mission forward. Through this act, she hopes their suffering will become part of the knowledge that saves others.

Episode Overview


Dr. Berretta’s path from Italy to Harvard

Why brain donation is essential

Why we cannot understand—or treat—mental illness without donated brains

Breakthrough research made possible by brain tissue


Psychiatric illness is a brain illness

What actually happens during brain donation

How to register as a brain donor

Why we urgently need more brain donors



Resources Mentioned
Harvard Brain Tissue Resource Center (HBTRC) – McLean Hospital
NIH Neurobiobank
Registration resources for brain donation
Information on brain tissue research for psychiatric illness

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